Titans of the Fortune 500
The Fortune 500 list is the definitive ranking of America’s largest corporations by revenue, offering a snapshot of the economic powerhouses driving the U.S. economy. In 2025, Walmart retains its crown as the top U.S. company by revenue, but the competition is fiercer than ever, with Amazon closing the gap and healthcare giants making significant strides.
This article dives deep into the top 10 U.S. companies by revenue in 2025, analyzing their financial dominance, industry influence, and future outlook. Whether you’re an investor, business enthusiast, or just curious about corporate America, this breakdown provides valuable insights into the companies shaping the global economy.
1. Walmart – $681 Billion: The Unstoppable Retail Giant
Walmart continues its reign as the largest U.S. company by revenue, posting $681 billion in FY 2024 sales 18. The retail behemoth has held the No. 1 spot for 13 consecutive years, thanks to its massive brick-and-mortar footprint and aggressive e-commerce expansion.
With 2.1 million employees, Walmart remains a dominant force in retail, leveraging automation and supply chain efficiency to stay ahead. The company’s revenue growth, though modest compared to tech giants, reflects its stability in uncertain economic climates.
Focus Keyword: largest U.S. company by revenue
2. Amazon – $638 Billion: The E-Commerce & Cloud Juggernaut
Amazon is hot on Walmart’s heels with $638 billion in revenue, marking the narrowest gap ever between the two retail titans . Beyond e-commerce, Amazon Web Services (AWS) remains a profit powerhouse, contributing significantly to its bottom line.
The company’s diversified revenue streams—spanning cloud computing, digital advertising, and logistics—make it a formidable competitor. Analysts predict Amazon could overtake Walmart in the coming years if its current growth trajectory holds.
Focus Keyword: top revenue-generating companies in the U.S.
3. UnitedHealth Group – $400 Billion: Healthcare’s Revenue Leader
UnitedHealth Group secures the third spot with $400 billion in revenue, reinforcing healthcare’s growing dominance in the Fortune 50017. As the largest health insurer in the U.S., UnitedHealth benefits from an aging population and rising medical costs.
The company’s Optum division, which focuses on pharmacy benefits and data analytics, is a major growth driver. With healthcare expenditures soaring, UnitedHealth’s revenue is expected to climb further in the coming years.
Focus Keyword: highest-revenue healthcare companies
4. Apple – $391 Billion: The Tech Titan’s Steady Climb
Despite a slight 2.8% revenue dip in 2024, Apple remains a top U.S. company by revenue at $391 billion9. The iPhone maker continues to thrive on premium product sales, services (like Apple Music and iCloud), and its growing wearables division.
Apple’s brand loyalty and ecosystem integration ensure steady revenue, even in competitive markets. With new AI-driven innovations on the horizon, Apple is poised to maintain its position among the highest-earning corporations.
Focus Keyword: top U.S. tech companies by revenue
5. CVS Health – $373 Billion: A Pharmacy & Healthcare Powerhouse
CVS Health rounds out the top five with $373 billion in revenue, thanks to its integrated healthcare model. The company’s acquisition of Aetna in 2018 transformed it into a full-service health provider, combining pharmacies, insurance, and clinics.
With 10.9% revenue growth in 2024, CVS Health is capitalizing on America’s healthcare needs. Its MinuteClinics and telehealth services are key differentiators in a crowded market.
Focus Keyword: largest healthcare companies in the U.S.
6. Berkshire Hathaway – $371 Billion: Warren Buffett’s Conglomerate
Berkshire Hathaway, led by Warren Buffett, generated $371 billion in revenue in 2024 . The conglomerate’s diverse holdings—from Geico insurance to BNSF Railway—provide stability across economic cycles.
Unlike other top companies, Berkshire’s revenue comes from multiple industries, making it uniquely resilient. Investors value its long-term growth strategy and strong cash reserves.
Focus Keyword: top diversified companies by revenue
7. Alphabet – $350 Billion: Google’s Parent Company
Alphabet, the parent company of Google, reported $350 billion in revenue, driven by advertising, cloud computing, and AI innovations19. Google Search and YouTube remain cash cows, while Google Cloud is rapidly expanding.
With 8.7% revenue growth, Alphabet continues to dominate digital advertising. Its investments in quantum computing and autonomous vehicles could fuel future revenue surges.
Focus Keyword: highest-revenue tech conglomerates
8. Exxon Mobil – $350 Billion: The Energy Giant’s Resurgence
Exxon Mobil ties with Alphabet at $350 billion in revenue, rebounding from previous declines . Despite the global push for renewables, oil demand remains strong, bolstering Exxon’s earnings.
The company’s cost-cutting measures and strategic investments in fossil fuels ensure profitability. However, long-term sustainability challenges loom as energy transitions accelerate.
Focus Keyword: top energy companies by revenue
9. McKesson – $309 Billion: The Pharmaceutical Distributor
McKesson, a leader in pharmaceutical distribution, posted $309 billion in revenue. The company plays a critical role in the U.S. healthcare supply chain, delivering medications to hospitals and pharmacies.
With an aging population and rising drug demand, McKesson’s revenue is expected to grow steadily. Its data analytics and specialty drug distribution segments are key growth areas.
Focus Keyword: largest pharmaceutical distributors
10. Cencora – $294 Billion: The Wholesale Pharmacy Leader
Formerly known as AmerisourceBergen, Cencora completes the top 10 with $294 billion in revenue18. The company specializes in drug wholesale and healthcare solutions, serving pharmacies and hospitals nationwide.
Cencora’s 9.9% revenue growth reflects strong demand for prescription drugs. Its global supply chain expertise ensures a steady revenue stream despite market fluctuations.
Focus Keyword: top pharmaceutical wholesalers by revenue
Key Trends from the 2025 Fortune 500 List
- Healthcare Dominance – Eight healthcare companies now rank in the top 25, up from zero in 1995 .
- Retail & Tech Rivalry – Walmart and Amazon’s revenue gap is the smallest ever at $43 billion .
- Female Leadership Rise – A record 55 female CEOs lead Fortune 500 firms, making up 11% of the list.
- California Leads – With 58 Fortune 500 HQs, California tops Texas (54) and New York (53) .
- Record Profits – Combined Fortune 500 profits hit $1.87 trillion, a historic high .
Conclusion: The Future of America’s Corporate Giants
The top 10 U.S. companies by revenue in 2025 highlight the shifting dynamics of the American economy. Walmart and Amazon dominate retail, UnitedHealth and CVS lead healthcare, and Apple and Alphabet drive tech innovation.
As AI, renewable energy, and healthcare reshape industries, these corporate titans must adapt to maintain their positions. One thing is certain: the Fortune 500 will continue to be a barometer of economic power for years to come.
For more insights, explore the full Fortune 500 list and see how these companies stack up against global competitors.
